I suppose the best place to start is with episode one. Takako. I like Takako. Most people don't seem to like her. In my opinion, I think she's a fairly strong character. She's at that point that everyone goes through at some time in their life. Pretty much everyone has some experience with running away from home. A lot of people don't make it past the doorstep.
      In Takako's case she has good reason to be running away. So she does. She's all alone and isn't sure who she can trust. She's just trying to get where she was told to go. People might think she's too mean to Chihaya or is too reluctant to accept help. But seriously. If you bumped into someone, and that person started following you everywhere for no apparent reason, would you immediately trust them?
      I liked Blair too. I thought she went very well with Cliff. She was as bulletproof as the rest of us when it came down to it (in other words, she's not bulletproof), but that doesn't make her a weak character. You might be a bit nervous if a gun was to your head too.
      Messiah I liked. He was a massive weapon of destruction. He was also practically a child. For some reason I think he's what Chihaya would look like if Chihaya was built like Kagetsuya or Messiah. In a way Chihaya is almost like his parent, considering he's made from Chihaya's DNA. Chihaya is the one who cares about him like a mother. I always think of them more in that mother/baby way than anything else. Messiah gains a lot of attributes from Chihaya, and I think it's cute when he has that strange naivety and he doesn't look like a character who should be naive.
      More than anything I think Messiah just needed some guidance, and if nothing else had been going on in the background (and Kagetsuya didn't dislike the bond between Chihaya and Messiah so much), I think Kagetsuya and Chihaya could have "raised" him. It would have been an interesting family.
      This is random, but I thought it was cute when Messiah was dressed up in those somewhat baggy 'street clothes' too. A really big guy just trying to blend in with the crowd.